Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Design and Synthesis of Deoxynucleic Guanidine: A Polycation Analogue of DNA

Robert O. Dempcy, Örn Almarsson and Thomas C. Bruice
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 17 (Aug. 16, 1994), pp. 7864-7868
Stable URL: http://www.jstor.org/stable/2365589
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Design and Synthesis of Deoxynucleic Guanidine: A Polycation Analogue of DNA
Preview not available

Abstract

The basic strategy is described for the connection of nucleosides by guanidinium (g) linkers to provide the positively charged deoxynucleic guanidine putative antigene agents. The synthetic procedures are provided for d(gT)n. Molecular modeling of double-stranded [d(gT)10· d(Ap)10] and the triple-helical hybrids [d(Tp)10· d(Ap)10· d(gT)10] and [d(gT)10· d(Ap)10· d(gT)10] suggest modes of interaction and anticipated structural features.

Page Thumbnails

  • Thumbnail: Page 
7864
    7864
  • Thumbnail: Page 
7865
    7865
  • Thumbnail: Page 
7866
    7866
  • Thumbnail: Page 
7867
    7867
  • Thumbnail: Page 
7868
    7868