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Cyclic Ca2+ Changes in Intracellular Stores of Gonadotropes During Gonadotropin-Releasing Hormone-Stimulated Ca2+ Oscillations
Frederick W. Tse, Amy Tse and Bertil Hille
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 21 (Oct. 11, 1994), pp. 9750-9754
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2365699
Page Count: 5
You can always find the topics here!Topics: Dyes, Fluorescence, Signals, Oscillation, Cytoplasm, Image processing, Pipettes, Digital images, Image contrast, Image enhancement
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Gonadotropin-releasing hormone induces oscillatory release of Ca2+ from inositol trisphosphate-sensitive stores of gonadotropes. Simultaneously with electrophysiological measures of cytoplasmic [Ca2+], corresponding changes in [Ca2+] within intracellular stores were monitored with a fluorescent dye, mag-indo-1. Each cycle of oscillation released only 10% of the detectable stored Ca2+. Some Ca2+ was recovered by the stores using a mechanism sensitive to inhibitors of intracellular Ca2+ ATPases, and much of the remainder was temporarily and rapidly pumped into other intracellular compartments or out of the cell. The dynamics of Ca2+ oscillations are thus more complex than a repeated emptying and refilling of a single compartment. The free concentrations measured show that intracellular Ca2+ store compartments contain strong Ca2+ buffers.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences