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Electrostatic Distance Geometry in a K+ Channel Vestibule

Martin Stocker and Christopher Miller
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 20 (Sep. 27, 1994), pp. 9509-9513
Stable URL: http://www.jstor.org/stable/2365866
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Electrostatic Distance Geometry in a K+ Channel Vestibule
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Abstract

Many voltage-gated K+ channels carry in the external vestibule a receptor for charybdotoxin, a peptide channel blocker. We use point mutagenesis of both charybdotoxin and a Shaker K+ channel to isolate the electrostatic interaction energy between chosen pairs of residues, one on the channel and one on bound toxin. The results allow estimates of physical distances between such residue pairs and, in combination with the known structure of charybdotoxin, localize specific channel residues in three-dimensional space.

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