You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Electrostatic Distance Geometry in a K+ Channel Vestibule
Martin Stocker and Christopher Miller
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 20 (Sep. 27, 1994), pp. 9509-9513
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2365866
Page Count: 5
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Many voltage-gated K+ channels carry in the external vestibule a receptor for charybdotoxin, a peptide channel blocker. We use point mutagenesis of both charybdotoxin and a Shaker K+ channel to isolate the electrostatic interaction energy between chosen pairs of residues, one on the channel and one on bound toxin. The results allow estimates of physical distances between such residue pairs and, in combination with the known structure of charybdotoxin, localize specific channel residues in three-dimensional space.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences