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Electrostatic Distance Geometry in a K+ Channel Vestibule
Martin Stocker and Christopher Miller
Proceedings of the National Academy of Sciences of the United States of America
Vol. 91, No. 20 (Sep. 27, 1994), pp. 9509-9513
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2365866
Page Count: 5
You can always find the topics here!Topics: Toxins, Electrostatics, Receptors, Biochemistry, Free energy, Molecules, Electrical potential, Symmetry, Electric current, Topographical elevation
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Many voltage-gated K+ channels carry in the external vestibule a receptor for charybdotoxin, a peptide channel blocker. We use point mutagenesis of both charybdotoxin and a Shaker K+ channel to isolate the electrostatic interaction energy between chosen pairs of residues, one on the channel and one on bound toxin. The results allow estimates of physical distances between such residue pairs and, in combination with the known structure of charybdotoxin, localize specific channel residues in three-dimensional space.
Proceedings of the National Academy of Sciences of the United States of America © 1994 National Academy of Sciences