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Intrinsic GABAergic System of Adrenal Chromaffin Cells
Y. Kataoka, Y. Gutman, A. Guidotti, P. Panula, J. Wroblewski, D. Cosenza-Murphy, J. Y. Wu and E. Costa
Proceedings of the National Academy of Sciences of the United States of America
Vol. 81, No. 10, [Part 1: Biological Sciences] (May 15, 1984), pp. 3218-3222
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/23659
Page Count: 5
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Histochemical and biochemical studies demonstrate that γ -aminobutyric acid (GABA), glutamic acid decarboxylase (EC 220.127.116.11), and GABA aminotransferase (EC 18.104.22.168) are present in bovine adrenal chromaffin cells. Moreover, [3H]GABA can be taken up and stored by primary cultures of adrenal chromaffin cells. Nicotinic receptor stimulation or KCl depolarization releases the [3H]GABA taken up by these cell cultures. GABA and benzodiazepine recognition sites located in chromaffin cells interact with each other with modalities similar to those described for GABA and benzodiazepine recognition sites located in synaptic membranes prepared from brain tissue. Bicuculline facilitates the release of catecholamine from chromaffin cells induced by nicotinic receptor stimulation but it fails to influence the release of catecholamine evoked by K+ depolarization. Since the GABA--benzodiazepine receptor system appears to modulate nicotinic receptor function, it is suggested that GABA transmission might participate in modulating responsiveness of chromaffin cells to incoming cholinergic stimuli.
Proceedings of the National Academy of Sciences of the United States of America © 1984 National Academy of Sciences