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Allonantigen Priming Induces a State of Unresponsiveness in Human Umbilical Cord Blood T Cells
Grant Ridson, Jay Gaddy, Masato Horie and Hal E. Broxmeyer
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 6 (Mar. 14, 1995), pp. 2413-2417
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2367004
Page Count: 5
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Induction of alloreactivity in human adult and umbilical cord blood T cells was evaluated in mixed leukocyte culture by exposure to an allogeneic lymphoblastoid line that expresses known costimulatory molecules. Initial exposure to alloantigen-presenting cells (allo-APC) induced strong proliferative responses in both adult and cord blood T cells. However, in contrast to adult T cells, cord blood T cells exhibited little proliferation after restimulation with donor APC. Primed cord blood T cells could respond to interleukin 2 (IL-2), but unresponsiveness to alloantigen was not overcome by addition of exogenous IL-2. Unresponsiveness was long-lasting and appeared to be maintained by a combination of induction of anergy and activity of CD8+ suppressor cells. This information may contribute to use of human cord blood as an allogeneic source of transplantable stem cells.
Proceedings of the National Academy of Sciences of the United States of America © 1995 National Academy of Sciences