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Allonantigen Priming Induces a State of Unresponsiveness in Human Umbilical Cord Blood T Cells

Grant Ridson, Jay Gaddy, Masato Horie and Hal E. Broxmeyer
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 6 (Mar. 14, 1995), pp. 2413-2417
Stable URL: http://www.jstor.org/stable/2367004
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Allonantigen Priming Induces a State of Unresponsiveness in Human Umbilical Cord Blood T Cells
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Abstract

Induction of alloreactivity in human adult and umbilical cord blood T cells was evaluated in mixed leukocyte culture by exposure to an allogeneic lymphoblastoid line that expresses known costimulatory molecules. Initial exposure to alloantigen-presenting cells (allo-APC) induced strong proliferative responses in both adult and cord blood T cells. However, in contrast to adult T cells, cord blood T cells exhibited little proliferation after restimulation with donor APC. Primed cord blood T cells could respond to interleukin 2 (IL-2), but unresponsiveness to alloantigen was not overcome by addition of exogenous IL-2. Unresponsiveness was long-lasting and appeared to be maintained by a combination of induction of anergy and activity of CD8+ suppressor cells. This information may contribute to use of human cord blood as an allogeneic source of transplantable stem cells.

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