Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

bcl-2 Transgene Expression can Protect Neurons Against Developmental and Induced Cell Death

Peter G. Farlie, Ralf Dringen, Sandra M. Rees, George Kannourakis and Ora Bernard
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 10 (May 9, 1995), pp. 4397-4401
Stable URL: http://www.jstor.org/stable/2367334
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
bcl-2 Transgene Expression can Protect Neurons Against Developmental and Induced Cell Death
Preview not available

Abstract

The bcl-2 protooncogene, which protects various cell types from apoptotic cell death, is expressed in the developing and adult nervous system. To explore its role in regulation of neuronal cell death, we generated transgenic mice expressing Bcl-2 under the control of the neuron-specific enolase promoter, which forced expression uniquely in neurons. Sensory neurons isolated from dorsal root ganglia of newborn mice normally require nerve growth factor for their survival in culture, but those from the bcl-2 transgenic mice showed enhanced survival in its absence. Furthermore, apoptotic death of motor neurons after axotomy of the sciatic nerve was inhibited in these mice. The number of neurons in two neuronal populations from the central and peripheral nervous system was increased by 30%, indicating that Bcl-2 expression can protect neurons from cell death during development. The generation of these transgenic mice suggests that Bcl-2 may play an important role in survival of neurons both during development and throughout adult life.

Page Thumbnails

  • Thumbnail: Page 
4397
    4397
  • Thumbnail: Page 
4398
    4398
  • Thumbnail: Page 
4399
    4399
  • Thumbnail: Page 
4400
    4400
  • Thumbnail: Page 
4401
    4401