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Bridging Grafts and Transient Nerve Growth Factor Infusions Promote Long-Term Central Nervous System Neuronal Rescue and Partial Functional Recovery
Mark H. Tuszynski and Fred H. Gage
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 10 (May 9, 1995), pp. 4621-4625
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2367379
Page Count: 5
You can always find the topics here!Topics: Neurons, Tissue grafting, Cholinergics, Hippocampus, Lesions, Brain, Physical trauma, Bridges, Habituation, Memory
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Grafts of favorable axonal growth substrates were combined with transient nerve growth factor (NGF) infusions to promote morphological and functional recovery in the adult rat brain after lesions of the septohippocampal projection. Long-term septal cholinergic neuronal rescue and partial hippocampal reinnervation were achieved, resulting in partial functional recovery on a simple task assessing habituation but not on a more complex task assessing spatial reference memory. Control animals that received transient NGF infusions without axonal-growth-promoting grafts lacked behavioral recovery but also showed long-term septal neuronal rescue. These findings indicate that (i) partial recovery from central nervous system injury can be induced by both preventing host neuronal loss and promoting host axonal regrowth and (ii) long-term neuronal loss can be prevented with transient NGF infusions.
Proceedings of the National Academy of Sciences of the United States of America © 1995 National Academy of Sciences