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A Potassium Channel β Subunit Related to the Aldo-Keto Reductase Superfamily is Encoded by the Drosophila Hyperkinetic Locus
Scott W. Chouinard, Gisela F. Wilson, A. Katherine Schlimgen and Barry Ganetzky
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 15 (Jul. 18, 1995), pp. 6763-6767
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2367732
Page Count: 5
You can always find the topics here!Topics: Oocytes, Electric potential, Amino acids, Drosophila, Complementary DNA, RNA, Genetics, Neurons, Genetic mutation, Time constants
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Genetic and physiological studies of the Drosophila Hyperkinetic (Hk) mutant revealed defects in the function or regulation of K+ channels encoded by the Shaker (Sh) locus. The Hk polypeptide, determined from analysis of cDNA clones, is a homologue of mammalian K+ channel β subunits (Kvβ). Coexpression of Hk with Sh in Xenopus oocytes increases current amplitudes and changes the voltage dependence and kinetics of activation and inactivation, consistent with predicted functions of Hk in vivo. Sequence alignments show that Hk, together with mammalian Kvβ, represents an additional branch of the aldo-keto reductase superfamily. These results are relevant to understanding the function and evolutionary origin of Kvβ.
Proceedings of the National Academy of Sciences of the United States of America © 1995 National Academy of Sciences