Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

A Potassium Channel β Subunit Related to the Aldo-Keto Reductase Superfamily is Encoded by the Drosophila Hyperkinetic Locus

Scott W. Chouinard, Gisela F. Wilson, A. Katherine Schlimgen and Barry Ganetzky
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 15 (Jul. 18, 1995), pp. 6763-6767
Stable URL: http://www.jstor.org/stable/2367732
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Potassium Channel β Subunit Related to the Aldo-Keto Reductase Superfamily is Encoded by the Drosophila Hyperkinetic Locus
Preview not available

Abstract

Genetic and physiological studies of the Drosophila Hyperkinetic (Hk) mutant revealed defects in the function or regulation of K+ channels encoded by the Shaker (Sh) locus. The Hk polypeptide, determined from analysis of cDNA clones, is a homologue of mammalian K+ channel β subunits (Kvβ). Coexpression of Hk with Sh in Xenopus oocytes increases current amplitudes and changes the voltage dependence and kinetics of activation and inactivation, consistent with predicted functions of Hk in vivo. Sequence alignments show that Hk, together with mammalian Kvβ, represents an additional branch of the aldo-keto reductase superfamily. These results are relevant to understanding the function and evolutionary origin of Kvβ.

Page Thumbnails

  • Thumbnail: Page 
6763
    6763
  • Thumbnail: Page 
6764
    6764
  • Thumbnail: Page 
6765
    6765
  • Thumbnail: Page 
6766
    6766
  • Thumbnail: Page 
6767
    6767