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An A-DNA Triplet Code: Thermodynamic Rules for Predicting A- and B-DNA

Beth Basham, Gary P. Schroth and P. Shing Ho
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 14 (Jul. 3, 1995), pp. 6464-6468
Stable URL: http://www.jstor.org/stable/2367863
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
An A-DNA Triplet Code: Thermodynamic Rules for Predicting A- and B-DNA
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Abstract

The ability to predict macromolecular conformations from sequence and thermodynamic principles has long been coveted but generally has not been achieved. We show that differences in the hydration of DNA surfaces can be used to distinguish between sequences that form A- and B-DNA. From this, a "triplet code" of A-DNA propensities was derived as energetic rules for predicting A-DNA formation. This code correctly predicted >90% of A- and B-DNA sequences in crystals and correlates with A-DNA formation in solution. Thus, with our previous studies on Z-DNA, we now have a single method to predict the relative stability of sequences in the three standard DNA duplex conformations.

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