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An A-DNA Triplet Code: Thermodynamic Rules for Predicting A- and B-DNA
Beth Basham, Gary P. Schroth and P. Shing Ho
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 14 (Jul. 3, 1995), pp. 6464-6468
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2367863
Page Count: 5
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The ability to predict macromolecular conformations from sequence and thermodynamic principles has long been coveted but generally has not been achieved. We show that differences in the hydration of DNA surfaces can be used to distinguish between sequences that form A- and B-DNA. From this, a "triplet code" of A-DNA propensities was derived as energetic rules for predicting A-DNA formation. This code correctly predicted >90% of A- and B-DNA sequences in crystals and correlates with A-DNA formation in solution. Thus, with our previous studies on Z-DNA, we now have a single method to predict the relative stability of sequences in the three standard DNA duplex conformations.
Proceedings of the National Academy of Sciences of the United States of America © 1995 National Academy of Sciences