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Neurotrophin 3 Rescues Neuronal Precursors From Apoptosis and Promotes Neuronal Differentiation in the Embryonic Metanephric Kidney

A. Karavanov, K. Sainio, J. Palgi, M. Saarma, L. Saxen and H. Sariola
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 24 (Nov. 21, 1995), pp. 11279-11283
Stable URL: http://www.jstor.org/stable/2368789
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Neurotrophin 3 Rescues Neuronal Precursors From Apoptosis and Promotes Neuronal Differentiation in the Embryonic Metanephric Kidney
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Abstract

We analyzed the developmental regulation and role of the neurotrophins during metanephric kidney morphogenesis. RNase protection assay revealed the presence of nerve growth factor, neurotrophin 3 (NT-3), and brain-derived neurotrophic factor mRNAs and the regulation of their expression during embryonic development of rat metanephros. NT-3 induced differentiation (neurite outgrowth) and survival (inhibition of apoptosis) of the neuronal precursors in cultured nephrogenic mesenchymes and neuronal differentiation in cultured whole kidneys, whereas NT-4/5, brain-derived neurotrophic factor, and nerve growth factor were without effect. The neurotrophins did not trigger tubular differentiation of isolated nephrogenic cells, which underwent apoptosis when cultured with or without the neurotrophins. NT-3 is thus an inducer of differentiation and a survival factor for renal neuronal cells, but none of the neurotrophins is a morphogen in kidney tubule induction.

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