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Inhibition of a Plant Virus Infection by Analogs of Melittin
Jose F. Marcos, Roger N. Beachy, Richard A. Houghten, Sylvie E. Blondelle and Enrique Perez-Paya
Proceedings of the National Academy of Sciences of the United States of America
Vol. 92, No. 26 (Dec. 19, 1995), pp. 12466-12469
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2369126
Page Count: 4
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An approach that enables identification of specific synthetic peptide inhibitors of plant viral infection is reported. Synthetic analogs of melittin that have sequence and structural similarities to an essential domain of tobacco mosaic virus coat protein were found to possess highly specific antiviral activity. This approach involves modification of residues located at positions analogous to those that are critical for virus assembly. The degree of inhibition found correlates well with sequence similarities between the viral capsid protein and the melittin analogs studied as well as with the induced conformational changes that result upon interaction of the peptides and ribonucleic acid.
Proceedings of the National Academy of Sciences of the United States of America © 1995 National Academy of Sciences