You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Sequence Variation and Evolution of Nuclear DNA in Man and the Primates
A. J. Jeffreys and P. A. Barrie
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Vol. 292, No. 1057, The Emergence of Man (May 8, 1981), pp. 133-142
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/2398651
Page Count: 10
You can always find the topics here!Topics: DNA, Primates, Nucleotide sequences, Species, Humans, Complementary DNA, Evolution, Divergent evolution, Genomes, Genetic variation
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Recent advances in nucleic acid technology have facilitated the detection and detailed structural analysis of a wide variety of genes in higher organisms, including those in man. This in turn has opened the way to an examination of the evolution of structural genes and their surrounding and intervening sequences. In a study of the evolution of haemoglobin genes and neighbouring sequences in man and the primates, we have investigated gene arrangement and DNA sequence divergence both within and between species ranging from Old World monkeys to man. This analysis is beginning to reveal the evolutionary constraints that have acted on this region of the genome during primate evolution. Furthermore, DNA sequence variation, both within and between species, provides, in principle, a novel and powerful method for determining interspecific phylogenetic distances and also for analysing the structure of present-day human populations. Application of this new branch of molecular biology to other areas of the human genome should prove important in unravelling the history of genetic changes that have occurred during the evolution of man.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences © 1981 Royal Society