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Studies of Natural Populations of Mus. II. Polymorphism at the T Locus

Michael L. Petras
Evolution
Vol. 21, No. 3 (Sep., 1967), pp. 466-478
DOI: 10.2307/2406608
Stable URL: http://www.jstor.org/stable/2406608
Page Count: 13
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Studies of Natural Populations of Mus. II. Polymorphism at the T Locus
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Abstract

1) An examination of mice collected over a four-year period from several localities in the vicinity of Ann Arbor, Michigan, revealed the existence of a polymorphism at the T locus. The overall adjusted frequency of the t-alleles at this locus was 0.162 ± .009. 2) The frequency estimates of the t-alleles varied considerably from one building to the next, ranging from 0 to 0.50. Also, the frequency estimates were found to fluctuate considerably from year to year in a single locality. 3) Complementation tests revealed the presence of at least three groups of alleles: two lethal and one viable. All but one of the lethals isolated were non-complementary and, therefore, considered identical. No attempt was made to further classify either the complementary lethals or the viable t-alleles. 4) Both lethal and viable t-alleles were frequently detected in mice from a single building. Approximately one-half of the t-alleles detected were viable. 5) The pooled male transmission ratios of the lethal and viable t-alleles were found to be 0.89 and 0.80 respectively. Female transmission ratios were normal. 6) These transmission ratios and an inbreeding coefficient determined from data at the Es-2 locus were incorporated into a deterministic population model with the result that the t-allele frequencies expected on the basis of this model were consistent with empirical frequencies.

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