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Testing the Constant-Rate Neutral Allele Model with Protein Sequence Data

Richard R. Hudson
Evolution
Vol. 37, No. 1 (Jan., 1983), pp. 203-217
DOI: 10.2307/2408186
Stable URL: http://www.jstor.org/stable/2408186
Page Count: 15
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Testing the Constant-Rate Neutral Allele Model with Protein Sequence Data
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Abstract

A method of testing the constant-rate neutral allele model of protein evolution is presented and applied to a large data set. The method uses the same statistic, χ2 LF, used by Langley and Fitch (1973, 1974) and Fitch and Langley (1976). The distribution of χ2 LF, characterized in this study with Monte Carlo simulations, depends on the parameter θ (=4Nu). The values of θ required to explain the observed value of χ2 LF are determined and found to be incompatible with the low levels of heterozygosity observed at the hemoglobin loci in humans. It is concluded that the constant-rate neutral model is highly improbable. Other neutral models and models involving natural selection need to be considered.

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