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The Manifestation of Phenotypic Selection at Constituent Loci. I. Stabilizing Selection

R. B. Campbell
Evolution
Vol. 38, No. 5 (Sep., 1984), pp. 1033-1038
DOI: 10.2307/2408437
Stable URL: http://www.jstor.org/stable/2408437
Page Count: 6
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The Manifestation of Phenotypic Selection at Constituent Loci. I. Stabilizing Selection
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Abstract

The effect of stabilizing phenotypic selection on the dynamics of allele frequencies at loci which govern the selected trait is investigated. Centripetal selection which restores the phenotypic optimum 0 by multiplying the mean phenotype by (1 - Ch2) is employed. It is found that the population mean is maintained sufficiently near the optimum so that directional selection contributes less than random drift to the dynamics of allele frequencies at individual loci (i.e., all loci are near neutral). However, if the population is sufficiently large, disruptive selection against new mutations becomes significant with the result that the total heterozygosity of the population is bounded, independent of population size. The model employed is a generalization of the fitness function w(x) = e-ax2 with additive non-epistasis between loci. The infinite loci model, which provides that the set of loci which are segregating varies over time, is also employed.

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