Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support

Epistasis as a Source of Increased Additive Genetic Variance at Population Bottlenecks

James M. Cheverud and Eric J. Routman
Evolution
Vol. 50, No. 3 (Jun., 1996), pp. 1042-1051
DOI: 10.2307/2410645
Stable URL: http://www.jstor.org/stable/2410645
Page Count: 10
  • Get Access
  • Read Online (Free)
  • Download ($4.00)
  • Cite this Item
If you need an accessible version of this item please contact JSTOR User Support
Epistasis as a Source of Increased Additive Genetic Variance at Population Bottlenecks
Preview not available

Abstract

The role of epistasis in evolution and speciation has remained controversial. We use a new parameterization of physiological epistasis to examine the effects of epistasis on levels of additive genetic variance during a population bottleneck. We found that all forms of epistasis increase average additive genetic variance in finite populations derived from initial populations with intermediate allele frequencies. Average additive variance continues to increase over many generations, especially at larger population sizes (N = 32 to 64). Additive-by-additive epistasis is the most potent source of additive genetic variance in this situation, whereas dominance-by-dominance epistasis contributes smaller amounts of additive genetic variance. With additive-by-dominance epistasis, additive genetic variance decreases at a relatively high rate immediately after a population bottleneck, rebounding to higher levels after several generations. Empirical examples of epistasis for murine adult body weight based on measured genotypes are provided illustrating the varying effects of epistasis on additive genetic variance during population bottlenecks.

Page Thumbnails

  • Thumbnail: Page 
1042
    1042
  • Thumbnail: Page 
1043
    1043
  • Thumbnail: Page 
1044
    1044
  • Thumbnail: Page 
1045
    1045
  • Thumbnail: Page 
1046
    1046
  • Thumbnail: Page 
1047
    1047
  • Thumbnail: Page 
1048
    1048
  • Thumbnail: Page 
1049
    1049
  • Thumbnail: Page 
1050
    1050
  • Thumbnail: Page 
1051
    1051