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Mechanism of Activation of an N-ras Oncogene of SW-1271 Human Lung Carcinoma Cells
Yasuhito Yuasa, Rose A. Gol, Audrey Chang, Ing-Ming Chiu, E. Premkumar Reddy, Steven R. Tronick and Stuart A. Aaronson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 81, No. 12, [Part 1: Biological Sciences] (Jun. 15, 1984), pp. 3670-3674
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/24334
Page Count: 5
You can always find the topics here!Topics: Oncogenes, DNA, DNA probes, Lungs, Cell lines, Exons, Lesions, Amino acids, Tumors, ras genes
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An N-ras-related transforming gene was detected in the human lung carcinoma cell line SW-1271 and molecularly cloned. The lesion responsible for its acquisition of transforming activity was localized to a single nucleotide transition from A to G in codon 61 of the predicted protein. This lesion in the second exon results in the substitution of arginine for glutamine at this position. These findings, together with previous studies, indicate that the activation of ras oncogenes in human tumors is most commonly due to point mutations at one of two major ``hot spots'' in the ras coding sequence.
Proceedings of the National Academy of Sciences of the United States of America © 1984 National Academy of Sciences