You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Bayesian Precision Profile for Measuring the Quality of Immunoassay Experiments
A. James O'Malley
Philosophical Transactions: Mathematical, Physical and Engineering Sciences
Vol. 366, No. 1874, Mathematical and Statistical Methods for Diagnoses and Therapies (Jul. 13, 2008), pp. 2301-2312
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/25190836
Page Count: 12
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
A precision profile, the relationship between the concentration of a substance and its measured precision, is a convenient way of conveying the ability of an immunoassay to accurately measure the concentration of a substance in blood serum. A precision profile is characterized by the definition of precision. Historically, precision has been evaluated as the standard error of an estimator of the concentration in a sample conditional on the true concentration. In this paper, Bayesian predictive inference is used to develop a new measure of precision based on the accuracy with which an assay could infer the concentration in a hypothetical new sample. This leads to a natural procedure for evaluating a precision profile that avoids using approximations such as those inherent in traditional methods.
Philosophical Transactions: Mathematical, Physical and Engineering Sciences © 2008 Royal Society