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Restriction Fragment Length Polymorphism of the Human C-Fms Gene

De Qi Xu, Stephane Guilhot and Francis Galibert
Proceedings of the National Academy of Sciences of the United States of America
Vol. 82, No. 9 (May 1, 1985), pp. 2862-2865
Stable URL: http://www.jstor.org/stable/25278
Page Count: 4
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Restriction Fragment Length Polymorphism of the Human C-Fms Gene
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Abstract

By using blot hybridization with a v-fms probe, a polymorphism for EcoRI, HindIII, and BamHI restriction endonuclease sites associated with the human c-fms locus was observed in a random adult population. This restriction fragment length polymorphism can be explained on the basis of the existence of two alleles, a and b, and is due to a short (≃ 500 base pairs) deletion characteristic of allele a. The distribution in the analyzed population (48 unrelated individuals) is 23% heterozygotes ab, 75% homozygotes bb, and 2% homozygotes aa. Though the inheritance of this polymorphism follows a Mendelian pattern, the children from couples ab × bb are of the following genotype: 74% ab and 26% bb. These deviations from the expected frequencies of 50% suggest a selective pressure in favor of heterozygotes.

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