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A Test for Differences between Treatment Means When Several Dose Levels are Compared with a Zero Dose Control

D. A. Williams
Biometrics
Vol. 27, No. 1 (Mar., 1971), pp. 103-117
DOI: 10.2307/2528930
Stable URL: http://www.jstor.org/stable/2528930
Page Count: 15
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A Test for Differences between Treatment Means When Several Dose Levels are Compared with a Zero Dose Control
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Abstract

Information on the biological activity of a substance is often obtained from experiments in which the treatments comprise a series of doses of the substance and a zero dose control. The aim of such experiments, particularly in toxicity studies, may be to determine the lowest dose, if any, at which there is activity. A new test procedure is proposed for this situation in the case where the activity of interest is a change in the mean of a single response variate. Tables are given whereby this procedure can be used when all treatments are equally replicated. The advantages of this test over other established tests are discussed.

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