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Composite Randomization Designs for Clinical Trials

Richard Simon
Biometrics
Vol. 37, No. 4 (Dec., 1981), pp. 723-731
DOI: 10.2307/2530154
Stable URL: http://www.jstor.org/stable/2530154
Page Count: 9
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Composite Randomization Designs for Clinical Trials
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Abstract

This paper proposes a new design for the augmentation of a randomized clinical trial through the participation of private physicians who do not randomize individual patients. Each private physician is randomly assigned a study treatment which he or she uses consistently for all eligible patients. A statistically rigorous method of analysis is described, the efficiency of this design is evaluated, and its limitations discussed.

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