If you need an accessible version of this item please contact JSTOR User Support

Optimal Sampling for Pedigree Analysis: Sequential Schemes for Sibships

E. A. Thompson
Biometrics
Vol. 37, No. 2 (Jun., 1981), pp. 313-325
DOI: 10.2307/2530420
Stable URL: http://www.jstor.org/stable/2530420
Page Count: 13
  • Download PDF
  • Cite this Item

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support
Optimal Sampling for Pedigree Analysis: Sequential Schemes for Sibships
Preview not available

Abstract

Methods for inferring the mode of inheritance of a trait from familial data are becoming widely used. It is therefore important to assess alternative procedures for the collection of the relevant data. Cannings and Thompson (1977, Clinical Genetics 12, 208-212) and Thompson and Cannings (1979. In Genetic Analysis of Common Diseases, 363-382. New York: Liss) have advocated sequential schemes on the grounds that these admit simple methods for the correction of the likelihood function for ascertainment bias. Here it is shown that sequential procedures may also greatly increase efficiency, as measured by (statistical) information gained per individual sampled. Although attention is restricted to sampling sibships, and to a simple genetic model, the measures introduced are more widely applicable. A practical procedure for the construction of schemes, via a relationship between expected log likelihood and entropy, is also presented. This too is more widely applicable. A numerical example demonstrates the gains which can be achieved in practice, relative to alternative hypotheses which have been considered in several medical-genetic studies.

Page Thumbnails

  • Thumbnail: Page 
313
    313
  • Thumbnail: Page 
314
    314
  • Thumbnail: Page 
315
    315
  • Thumbnail: Page 
316
    316
  • Thumbnail: Page 
317
    317
  • Thumbnail: Page 
318
    318
  • Thumbnail: Page 
319
    319
  • Thumbnail: Page 
320
    320
  • Thumbnail: Page 
321
    321
  • Thumbnail: Page 
322
    322
  • Thumbnail: Page 
323
    323
  • Thumbnail: Page 
324
    324
  • Thumbnail: Page 
325
    325