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The Crossover Experiment for Clinical Trials
Byron Wm. Brown, Jr.
Vol. 36, No. 1 (Mar., 1980), pp. 69-79
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/2530496
Page Count: 11
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The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of carryover effects is investigated and found to be uneconomical. A numerical example is presented.
Biometrics © 1980 International Biometric Society