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The Crossover Experiment for Clinical Trials

Byron Wm. Brown, Jr.
Biometrics
Vol. 36, No. 1 (Mar., 1980), pp. 69-79
DOI: 10.2307/2530496
Stable URL: http://www.jstor.org/stable/2530496
Page Count: 11
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The Crossover Experiment for Clinical Trials
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Abstract

The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of carryover effects is investigated and found to be uneconomical. A numerical example is presented.

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