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Regressive Logistic Models for Familial Disease and Other Binary Traits
George Ebow Bonney
Vol. 42, No. 3 (Sep., 1986), pp. 611-625
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/2531211
Page Count: 15
You can always find the topics here!Topics: Disease models, Phenotypic traits, Genetics, Epidemiology, Statistical models, Modeling, Spouses, Regression analysis, Logistics, Parametric models
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The simple Markovian structures of dependence, defined previously for continuous traits, are extended here to familial disease and other binary traits through the use of the logistic function. The regressive models so formulated can incorporate explanatory variables and major gene effects for segregation and linkage analyses. Thus, the goals of epidemiology and genetics in the analysis of familial disease can be accomplished in the same computational scheme.
Biometrics © 1986 International Biometric Society