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Design of Two-Phase Prevalence Surveys of Rare Disorders
Patrick E. Shrout and Stephen C. Newman
Vol. 45, No. 2 (Jun., 1989), pp. 549-555
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/2531496
Page Count: 7
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Two-phase medical surveys, in which a large sample is assessed with an inexpensive screening instrument and a subsample is selected for a more thorough diagnostic evaluation, appear to have great merit in the epidemiologic study of certain rare disorders. We present the optimal design of two-phase surveys when resources are fixed and when 100% of those screened positive in the first phase must be included in the second-phase evaluation. We go on to examine the relative efficiency of this two-phase design compared to a single-phase design in which all resources are used in a survey that employs the diagnostic evaluation. Given information on the accuracy of the screen and the prevalence of the disorder, the utility of the two-phase design depends on the relative cost of the screening to the diagnostic assessments.
Biometrics © 1989 International Biometric Society