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Analysis of In-situ Hybridization Data for Unique Genes Using GLIM
David J. Scott and Andrew H. Sinclair
Vol. 45, No. 2 (Jun., 1989), pp. 601-604
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/2531500
Page Count: 4
You can always find the topics here!Topics: Chromosomes, Genetic hybridization, Genes, Maximum likelihood estimators, Regression analysis, Biometrics, Background radiation, Silver, Signals, Parametric models
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When a radioactively-labelled gene probe is hybridized to chromosomes on a microscope slide, the site of hybridization should be revealed by counting emitted β-particles on a photographic overlay. However, in some cases background radiation disguises the site of hybridization. Using GLIM to fit Poisson regression models, it is possible to determine the chromosome to which the gene has hybridized.
Biometrics © 1989 International Biometric Society