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An Exact Test for Hardy-Weinberg and Multiple Alleles
Edward J. Louis and Everett R. Dempster
Vol. 43, No. 4 (Dec., 1987), pp. 805-811
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/2531534
Page Count: 7
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Algorithms for generating the exact distribution of a finite sample drawn from a population in Hardy-Weinberg equilibrium are given for multiple alleles. The finite sampling distribution is derived analogously to Fisher's 2 X 2 exact distribution and is equivalent to Levene's conditional finite sampling distribution for Hardy-Weinberg populations. The algorithms presented are fast computationally and allow for quick alternatives to standard methods requiring corrections and approximations. Computation time is on the order of a few seconds for three-allele examples and up to 2 minutes for four-allele examples on an IBM 3081 machine.
Biometrics © 1987 International Biometric Society