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A Discrete-Time Model of the Acquistin of Antibiotic-Resistant Infections in Hospitalized Patients

Alan M. Garber
Biometrics
Vol. 45, No. 3 (Sep., 1989), pp. 797-816
DOI: 10.2307/2531684
Stable URL: http://www.jstor.org/stable/2531684
Page Count: 20
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Discrete-Time Model of the Acquistin of Antibiotic-Resistant Infections in Hospitalized Patients
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Abstract

Antibiotic use is thought to promote bacterial antibiotic resistance by selectively inhibiting the growth of sensitive strains. This study investigates the relation between antibiotic use and the propagation of antibiotic-resistant hospital-acquired infections due to gram-negative bacteria in a population of hospitalized patients. It treats infection spread and hospital mortality as a Markov process, in which the transition probabilities are logistic functions of a set of personal and hospital characteristics. Data from a university hospital are used to derive the parameters of the model.

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