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Monitoring Accumulating Data in a Clinical Trial

Donald A. Berry
Biometrics
Vol. 45, No. 4 (Dec., 1989), pp. 1197-1211
DOI: 10.2307/2531771
Stable URL: http://www.jstor.org/stable/2531771
Page Count: 15
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Monitoring Accumulating Data in a Clinical Trial
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Abstract

A clinical trial is monitored for efficacy or safety; the variable of interest is death or a similarly serious event. The probability that one therapy has a greater mortality rate than the other is calculated ad libitum during the trial. Adjustments are made for differing patients' prognoses and for survival times.

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