Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Epidemiologic Assessment of Risks of Adverse Reactions Associated with Intermittent Exposure

Uwe Feldmann
Biometrics
Vol. 49, No. 2 (Jun., 1993), pp. 419-428
DOI: 10.2307/2532555
Stable URL: http://www.jstor.org/stable/2532555
Page Count: 10
  • Read Online (Free)
  • Download ($14.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Epidemiologic Assessment of Risks of Adverse Reactions Associated with Intermittent Exposure
Preview not available

Abstract

Measures of risk of adverse reactions, such as the absolute risk, the relative risk, and the excess risk, are analyzed for individuals who are exposed occasionally for periods of varying duration. This type of exposure is of particular importance for the epidemiologic assessment of drug safety. A Poisson point process model that allows for the simultaneous consideration of concomitant factors is derived for the estimation of the hazard rates. The model can judge acute adverse reactions and is applicable not only for rare risks since an undesired effect may occur repeatedly for an individual. Hazard estimation is achieved with the aid of the maximum likelihood method for several sampling designs, such as cohort studies, case-cohort studies, and case studies. In the latter design only those individuals who have had an adverse reaction during the time of observation are considered for hazard estimation. An application to the analysis of wound-healing impairments is given.

Page Thumbnails

  • Thumbnail: Page 
419
    419
  • Thumbnail: Page 
420
    420
  • Thumbnail: Page 
421
    421
  • Thumbnail: Page 
422
    422
  • Thumbnail: Page 
423
    423
  • Thumbnail: Page 
424
    424
  • Thumbnail: Page 
425
    425
  • Thumbnail: Page 
426
    426
  • Thumbnail: Page 
427
    427
  • Thumbnail: Page 
428
    428