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Estimating Drug Shelf-Life with Random Batches
Shein-Chung Chow and Jun Shao
Vol. 47, No. 3 (Sep., 1991), pp. 1071-1079
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/2532659
Page Count: 9
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The problem of assessing the shelf-lives of drug products in the market is considered. We focus on the situation where the drug characteristic of interest has a linear relationship over time and batch-to-batch variation is present. Two methods for assessing shelf-lives are proposed based on the weighted least squares method under a regression model with random coefficients. An application to some stability data from the pharmaceutical industry is presented.
Biometrics © 1991 International Biometric Society