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Interval Mapping in the Analysis of Nonadditive Quantitative Trait Loci
E. A. Carbonell, T. M. Gerig, E. Balansard and M. J. Asins
Vol. 48, No. 1 (Mar., 1992), pp. 305-315
Published by: International Biometric Society
Stable URL: http://www.jstor.org/stable/2532757
Page Count: 11
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A method for detecting the linkage between an interval defined by a pair of markers and a nonadditive quantitative trait locus for F2 populations is presented. The method uses the EM algorithm to estimate the biometrical parameters and the locations of the quantitative trait loci. A computationally efficient approach suitable for implementation on a personal computer (PC) has been developed. The method has been applied to 100 replicated sets of 250 simulated individuals. Two criteria, the LOD score and the Fisher-Snedecor F, are compared in terms of their power and Type I error.
Biometrics © 1992 International Biometric Society