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Comparing Power of Different Methods for QTL Detection

Ahmed Rebai, Bruno Goffinet and Brigitte Mangin
Biometrics
Vol. 51, No. 1 (Mar., 1995), pp. 87-99
DOI: 10.2307/2533317
Stable URL: http://www.jstor.org/stable/2533317
Page Count: 13
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Comparing Power of Different Methods for QTL Detection
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Abstract

We compared the powers of two methods for detection of quantitative trait loci (QTL) using genetic markers, in the simple case of an interval between two codominant markers and a backcross population. The first method is the interval mapping approach, based on the use of likelihood ratio tests performed in many positions within the interval considered and the second is the classical analysis of variance (ANOVA) testing only on the positions of the two markers. For both approaches we took into account the correlation between tests performed at different markers or positions in the interval. Appropriate thresholds and powers of tests were then calculated using analytical formulations. Simulations were also done to check the validity of the approximations used to calculate the power of the interval mapping test. Results show that the interval mapping test is slightly more powerful (about 5%) than ANOVA for small intervals (less than 20 cM) and that, for quite large effects of the QTL, the advantage of interval mapping increases as the distance between markers increases. It is more than 30% for intervals of about 70 cM.

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