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Pulmonary Emphysema And α₁-Antitrypsin Deficiency

D. C. S. Hutchison, P. J. L. Cook, C. E. Barter, Harry Harris and P. Hugh-Jones
The British Medical Journal
Vol. 1, No. 5751 (Mar. 27, 1971), pp. 689-694
Published by: BMJ
Stable URL: http://www.jstor.org/stable/25413793
Page Count: 6
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Pulmonary Emphysema And α₁-Antitrypsin Deficiency
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Abstract

Of 72 patients with radiological evidence of pulmonary emphysema, emphysema occurred either alone or in association with bronchitis in 61, and 8 of these (13%) were found to have α₁-antitrypsin deficiency. The main features of this condition are: exertional dyspnoea of relatively early onset (generally between 30 and 45 years of age), severely impaired FEV₁ and ${\rm T}_{{\rm L}}{\rm co}$, and radiological emphysema predominantly affecting the lower zones of the lungs. It is probable that any patient with all the above abnormalities has α₁-antitrypsin deficiency. There is evidence to suggest that cigarette smoking may hasten the onset of this type of emphysema.

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