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Diagnosis Of Established Deep Vein Thrombosis With The ¹²⁵I Fibrinogen Uptake Test
N. L. Browse, W. F. Clapham, D. N. Croft, D. J. Jones, M. Lea Thomas and J. Olwen Williams
The British Medical Journal
Vol. 4, No. 5783 (Nov. 6, 1971), pp. 325-328
Published by: BMJ
Stable URL: http://www.jstor.org/stable/25416471
Page Count: 4
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One hundred and two patients with clinical signs indicating a possible diagnosis of deep vein thrombosis were studied with the fibrinogen uptake test and phlebography to assess the reliability of the test as a means of diagnosing established venous thrombosis. The test gave a correct diagnosis in 78% of the 85 legs shown to contain thrombus by phlebography and only 19 (10%) false-negative results in the 195 legs examined. The duration of the symptoms, the administration of anticoagulants, and mild leg swelling did not affect the accuracy of the test. Very old thrombus, phlebographically more than 11 days old, was associated with an increased false-negative rate. The fibrinogen uptake test is accurate enough to make it a valuable method of clinical investigation.
The British Medical Journal © 1971 BMJ