You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Development of Distinct Control Networks through Segregation and Integration
Damien A. Fair, Nico U. F. Dosenbach, Jessica A. Church, Alexander L. Cohen, Shefali Brahmbhatt, Francis M. Miezin, Deanna M. Barch, Marcus E. Raichle, Steven E. Petersen and Bradley L. Schlaggar
Proceedings of the National Academy of Sciences of the United States of America
Vol. 104, No. 33 (Aug. 14, 2007), pp. 13507-13512
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/25436514
Page Count: 6
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Human attentional control is unrivaled. We recently proposed that adults depend on distinct frontoparietal and cinguloopercular networks for adaptive online task control versus more stable set control, respectively. During development, both experience-dependent evoked activity and spontaneous waves of synchronized cortical activity are thought to support the formation and maintenance of neural networks. Such mechanisms may encourage tighter "integration" of some regions into networks over time while "segregating" other sets of regions into separate networks. Here we use resting state functional connectivity MRI, which measures correlations in spontaneous blood oxygenation level-dependent signal fluctuations between brain regions to compare previously identified control networks between children and adults. We find that development of the proposed adult control networks involves both segregation (i.e., decreased short-range connections) and integration (i.e., increased long-range connections) of the brain regions that comprise them. Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome.
Proceedings of the National Academy of Sciences of the United States of America © 2007 National Academy of Sciences