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Synchronized Delta Oscillations Correlate with the Resting-State Functional MRI Signal
Hanbing Lu, Yantao Zuo, Hong Gu, James A. Waltz, Wang Zhan, Clara A. Scholl, William Rea, Yihong Yang and Elliot A. Stein
Proceedings of the National Academy of Sciences of the United States of America
Vol. 104, No. 46 (Nov. 13, 2007), pp. 18265-18269
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/25450408
Page Count: 5
You can always find the topics here!Topics: Magnetic resonance imaging, Signals, Anesthetics, Electrodes, Connectivity, Anesthesia, Visual cortex, Correlations, Brain, Vibrational frequencies
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Synchronized low-frequency spontaneous fluctuations of the functional MRI (fMRI) signal have recently been applied to investigate large-scale neuronal networks of the brain in the absence of specific task instructions. However, the underlying neural mechanisms of these fluctuations remain largely unknown. To this end, electrophysiological recordings and resting-state fMRI measurements were conducted in α-chloralose-anesthetized rats. Using a seed-voxel analysis strategy, region-specific, anesthetic dose-dependent fMRI resting-state functional connectivity was detected in bilateral primary somatosensory cortex (S1FL) of the resting brain. Cortical electroencephalographic signals were also recorded from bilateral S1FL; a visual cortex locus served as a control site. Results demonstrate that, unlike the evoked fMRI response that correlates with power changes in the γ bands, the resting-state fMRI signal correlates with the power coherence in low-frequency bands, particularly the δ band. These data indicate that hemodynamic fMRI signal differentially registers specific electrical oscillatory frequency band activity, suggesting that fMRI may be able to distinguish the ongoing from the evoked activity of the brain.
Proceedings of the National Academy of Sciences of the United States of America © 2007 National Academy of Sciences