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SUMOylation of Pontin Chromatin-Remodeling Complex Reveals a Signal Integration Code in Prostate Cancer Cells
Jung Hwa Kim, Ji Min Lee, Hye Jin Nam, Hee June Choi, Jung Woo Yang, Jason S. Lee, Mi Hyang Kim, Su-Il Kim, Chin Ha Chung, Keun Il Kim and Sung Hee Baek
Proceedings of the National Academy of Sciences of the United States of America
Vol. 104, No. 52 (Dec. 26, 2007), pp. 20793-20798
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/25450980
Page Count: 6
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Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of transcription factors and coregulators and participates in various cellular processes including signal transduction and transcriptional regulation. Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active control mechanism for the transcriptional regulation of pontin on androgen-receptor target genes in prostate cancer cells. Biochemical purification of pontin-containing complexes revealed the presence of the Ubc9 SUMO-conjugating enzyme that underlies its function as an activator. Intriguingly, 5α-dihydroxytestosterone treatments significantly increased the SUMOylation of pontin, and SUMOylated pontin showed further activation of a subset of nuclear receptor-dependent transcription and led to an increase in proliferation and growth of prostate cancer cells. These data clearly define a functional model and provide a link between SUMO modification and prostate cancer progression.
Proceedings of the National Academy of Sciences of the United States of America © 2007 National Academy of Sciences