You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Histone Demethylase Is Necessary for Regeneration in Zebrafish
Scott Stewart, Zhi-Yang Tsun and Juan Carlos Izpisua Belmonte
Proceedings of the National Academy of Sciences of the United States of America
Vol. 106, No. 47 (Nov. 24, 2009), pp. 19889-19894
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/25593294
Page Count: 6
You can always find the topics here!Topics: Histones, Chromatin, Genes, Animal fins, Regeneration, Pluripotent stem cells, Amputation, Embryonic stem cells, T lymphocytes, Stem cells
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Urodele amphibians and teleost fish regenerate amputated body parts via a process called epimorphic regeneration. A hallmark of this phenomenon is the reactivation of silenced developmental regulatory genes that previously functioned during embryonic patterning. We demonstrate that histone modifications silence promoters of numerous genes involved in zebrafish caudal fin regeneration. Silenced developmental regulatory genes contain bivalent me³K4/me³K27 H3 histone modifications created by the concerted action of Polycomb (PcG) and Trithorax histone methyltransferases. During regeneration, this silent, bivalent chromatin is converted to an active state by loss of repressive me³K27 H3 modifications, occurring at numerous genes that appear to function during regeneration. Loss-of-function studies demonstrate a requirement for a me³K27 H3 demethylase during fin regeneration. These results indicate that histone modifications at discreet genomic positions may serve as a crucial regulatory event in the initiation of fin regeneration.
Proceedings of the National Academy of Sciences of the United States of America © 2009 National Academy of Sciences