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Outdoor air pollution is associated with rapid decline of lung function in α-1-antitrypsin deficiency
Alice M Wood, Roy M Harrison, Sean Semple, Jon G Ayres and Robert A Stockley
Occupational and Environmental Medicine
Vol. 67, No. 8 (August 2010), pp. 556-561
Published by: BMJ
Stable URL: http://www.jstor.org/stable/25701708
Page Count: 6
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Introduction Outdoor air pollutants are associated with respiratory morbidity and mortality, but little longitudinal work has been undertaken in this area in chronic obstructive pulmonary disease (COPD). Patients with α-1-antitrypsin deficiency (AATD) typically exhibit faster decline of lung function than subjects with usual COPD and thus represent a group in whom studies of factors influencing decline may be more easily clarified. Methods Decline of FEV₁ and KCO in subjects of the PiZZ genotype from the UK AATD registry were studied. Pollution levels (PM₁₀, ozone, sulphur dioxide, nitrogen dioxide) during the exposure window were extracted from GIS maps, matching the measurement to each patient's home address. Clinical predictors of decline were sought using generalised estimating equations, and pollutants added to these subsequently. Single pollutant models were used due to multicollinearity. Results In the FEV₁ decline analysis, higher baseline FEV₁ was associated with rapid decline of FEV₁ (p<0.001). High PM₁₀ exposure predicted more rapid decline of FEV₁ (p=0.024). In a similar analysis for KCO decline, higher baseline KCO predicted rapid decline (p<0.001) as did higher exposure to ozone (p=0.018). High PM₁₀ exposure also showed a trend towards this effect (p=0.056). Conclusions Exposure to ozone and PM₁₀ predicts decline of lung function in AATD.
Occupational and Environmental Medicine © 2010 BMJ