Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Theoretical Problems Related to the Attachment of Microtubules to Kinetochores

Terrell L. Hill
Proceedings of the National Academy of Sciences of the United States of America
Vol. 82, No. 13 (Jul. 1, 1985), pp. 4404-4408
Stable URL: http://www.jstor.org/stable/25812
Page Count: 5
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Theoretical Problems Related to the Attachment of Microtubules to Kinetochores
Preview not available

Abstract

A possible model is analyzed for the maintenance of attachment of a shortening microtubule (MT) to a kinetochore. In this model it is assumed that a MT is inserted and held in a sleeve or channel of the outer layer of a kinetochore while subunits are lost from the MT tip through the central layer of the kinetochore. A second problem considered is the elementary bioenergetics of MT growth and shortening, as associated with the presence or absence of a GTP cap on the MT ends. The free-energy source is the hydrolysis of GTP in solution. The third problem discussed is the kinetics of capture of a centrosomal MT by a target (e.g., a kinetochore).

Page Thumbnails

  • Thumbnail: Page 
4404
    4404
  • Thumbnail: Page 
4405
    4405
  • Thumbnail: Page 
4406
    4406
  • Thumbnail: Page 
4407
    4407
  • Thumbnail: Page 
4408
    4408