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Theoretical Problems Related to the Attachment of Microtubules to Kinetochores
Terrell L. Hill
Proceedings of the National Academy of Sciences of the United States of America
Vol. 82, No. 13 (Jul. 1, 1985), pp. 4404-4408
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/25812
Page Count: 5
You can always find the topics here!Topics: Polymers, Sleeves, Kinetochores, Centrosomes, Monomers, Hydrolysis, Kinetics, Free energy, Metaphase, Microtubules
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A possible model is analyzed for the maintenance of attachment of a shortening microtubule (MT) to a kinetochore. In this model it is assumed that a MT is inserted and held in a sleeve or channel of the outer layer of a kinetochore while subunits are lost from the MT tip through the central layer of the kinetochore. A second problem considered is the elementary bioenergetics of MT growth and shortening, as associated with the presence or absence of a GTP cap on the MT ends. The free-energy source is the hydrolysis of GTP in solution. The third problem discussed is the kinetics of capture of a centrosomal MT by a target (e.g., a kinetochore).
Proceedings of the National Academy of Sciences of the United States of America © 1985 National Academy of Sciences