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Expression of the Cytokeratin Endo A Gene during Early Mouse Embryogenesis
Philippe Duprey, Dominique Morello, Marc Vasseur, Charles Babinet, Hubert Condamine, Philippe Brulet and Francois Jacob
Proceedings of the National Academy of Sciences of the United States of America
Vol. 82, No. 24 (Dec. 15, 1985), pp. 8535-8539
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/26624
Page Count: 5
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Expression of cytokeratin endo A has been analyzed during mouse blastocyst formation and embryonal carcinoma cell differentiation. To study the regulation of endo A expression, nuclease S1 mapping experiments have been performed on RNA extracted from two-cell to 7.5-day embryos. Low levels of endo A mRNA begin to be detectable in eight-cell embryos. The amount of this mRNA increases at the blastocyst stage, suggesting that endo A expression is regulated at the mRNA level during blastocyst formation. At this stage, in situ hybridization studies show that endo A mRNA is present in the trophectoderm but not in the inner cell mass. In 7.5-day embryos, endo A mRNAs are also detectable in the endoderm layer and in the amnion.
Proceedings of the National Academy of Sciences of the United States of America © 1985 National Academy of Sciences