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Higher Macrophage Inflammatory Protein (MIP)-1α and MIP-1β Levels from CD8+ T Cells Are Associated with Asymptomatic HIV-1 Infection
Fiorenza Cocchi, Anthony L. DeVico, Robert Yarchoan, Robert Redfield, Farley Cleghorn, William A. Blattner, Alfredo Garzino-Demo, Sandra Colombini-Hatch, David Margolis and Robert C. Gallo
Proceedings of the National Academy of Sciences of the United States of America
Vol. 97, No. 25 (Dec. 5, 2000), pp. 13812-13817
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/2666452
Page Count: 6
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To test the hypothesis that β-chemokine levels may be relevant to the control of HIV in vivo, we compared RANTES, MIP-1α, and MIP-1β production from purified CD8+ T cells from 81 HIV-infected subjects and from 28 uninfected donors. Asymptomatic HIV+ subjects produced significantly higher levels of MIP-1α and MIP-1β, but not RANTES, than uninfected donors or patients that progressed to AIDS. In contrast, β chemokines in plasma were either nondetectable or showed no correlation with clinical status. The high β-chemokine-mediated anti-HIV activity was against the macrophage tropic isolate HIV-1BAL, with no demonstrable effect on the replication of the T-cell tropic HIV-1IIIB. These findings suggest that constitutive β-chemokine production may play an important role in the outcome of HIV-1 infection.
Proceedings of the National Academy of Sciences of the United States of America © 2000 National Academy of Sciences