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Locating a Nucleotide-Binding Site in the Thymidine Kinase of Vaccinia Virus and of Herpes Simplex Virus by Scoring Triply Aligned Protein Sequences

Glenn A. Gentry
Proceedings of the National Academy of Sciences of the United States of America
Vol. 82, No. 20 (Oct. 15, 1985), pp. 6815-6819
Stable URL: http://www.jstor.org/stable/26711
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Locating a Nucleotide-Binding Site in the Thymidine Kinase of Vaccinia Virus and of Herpes Simplex Virus by Scoring Triply Aligned Protein Sequences
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Abstract

Computer techniques were used to locate related segments of amino acid sequences in the thymidine kinases of vaccinia virus and of herpes simplex virus type 1 and in porcine adenylate kinase. As determined by a procedure that evaluates triply aligned sequences, the probability that the similarities among the segments described here arose by chance was no greater than 0.001. Because the sequence in porcine adenylate kinase is a nucleotide phosphate-binding site it is concluded that the segments in the vaccinia virus and herpes simplex virus thymidine kinases perform similar functions. The segments are residues 16-23 in porcine adenylate kinase, 11-19 in vaccinia virus thymidine kinase, and 56-64 in herpes simplex virus thymidine kinase.

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