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Adjusting for Regression Effect in Uncontrolled Studies

Joshua D. Naranjo and Joseph W. McKean
Biometrics
Vol. 57, No. 1 (Mar., 2001), pp. 178-181
Stable URL: http://www.jstor.org/stable/2676857
Page Count: 4
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Adjusting for Regression Effect in Uncontrolled Studies
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Abstract

When clinical studies require enrolled patients to have abnormal assays, the natural tendency of repeat measurements to regress toward the mean can lead to a false assessment of effectiveness of therapy. We propose a method to more accurately estimate the true effect of therapy by adjusting for a component of improvement that can be attributed to regression effect. The model we use allows for a combination of additive and/or multiplicative effects of the therapy.

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