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A General Model for Estimating ED100p for Binary Response Dose- Response Data

Thérèse A. Stukel
The American Statistician
Vol. 44, No. 1 (Feb., 1990), pp. 19-22
DOI: 10.2307/2684950
Stable URL: http://www.jstor.org/stable/2684950
Page Count: 4
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A General Model for Estimating ED100p for Binary Response Dose- Response Data
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Abstract

A class of models, indexed by two shape parameters, was proposed as a generalization to the standard logistic model by Stukel (1988). In the context of binary response dose-response models, this class provides a more general framework for estimating the dose associated with a specific risk. Expressions for the maximum likelihood estimates and standard errors of such a dose are presented. In cases where the logistic model fitted poorly in the tails, improved dose estimates were obtained.

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