Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Mineral Fibres: Correlation between Oxidising Surface Activity and DNA Base Hydroxylation

A. Nejjari, J. Fournier, H. Pezerat and P. Leanderson
British Journal of Industrial Medicine
Vol. 50, No. 6 (Jun., 1993), pp. 501-504
Published by: BMJ
Stable URL: http://www.jstor.org/stable/27727640
Page Count: 4
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Mineral Fibres: Correlation between Oxidising Surface Activity and DNA Base Hydroxylation
Preview not available

Abstract

In relation to their potential genotoxic properties, the ability of inorganic particles to induce activated species of oxygen with strong oxidative properties can be studied by various methods. In this study the oxidative surface properties of 10 different natural and synthetic mineral fibres were investigated by: (1) an electron paramagnetic resonance technique in which formate was used to trap oxidative species; and (2) a high performance liquid chromatography (HPLC) based method in which deoxyguanosine was used as a trapping agent and the formation of 8-hydroxy-deoxyguanosine (8 OHdG) was analysed. Ground iron-containing fibres such as crocidolite and amosite were the most reactive, whereas fibres without iron—for example, ceramic fibres, xonotlite, and Tismo L—were completely inactive. A good correlation was found when the results from the two methods were compared (r = 0·86).

Page Thumbnails

  • Thumbnail: Page 
501
    501
  • Thumbnail: Page 
502
    502
  • Thumbnail: Page 
503
    503
  • Thumbnail: Page 
504
    504