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Cellular myc (c-myc) in Fish (Rainbow Trout): Its Relationship to Other Vertebrate myc Genes and to the Transforming Genes of the MC29 Family of Viruses
R. J. Van Beneden, D. K. Watson, T. T. Chen, J. A. Lautenberger and T. S. Papas
Proceedings of the National Academy of Sciences of the United States of America
Vol. 83, No. 11 (Jun. 1, 1986), pp. 3698-3702
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/27753
Page Count: 5
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We have isolated, cloned, and sequenced the rainbow trout (Salmo gairdneri) c-myc gene. The presumptive coding region of the trout c-myc gene shows extensive homology to the c-myc genes of chicken, mouse, and human. Comparison of nucleotide sequences reveals that human, mouse, chicken, and trout c-myc genes contain at least two coding exons, interrupted by introns of decreasing size of 1.38 kilobases (kb), 1.2 kb, 0.97 kb, and 0.33 kb, respectively. The exons are clearly delineated by donor-acceptor splice signals. The degree of nucleotide homology between trout, chicken, and human exon II is less than that observed for exon III. However, the greatest homology among these three genes is localized to two specific regions within exon II (myc boxes A and B). At the predicted amino acid level, fish c-myc shows considerable homology to vertebrate c-myc gene products. Trout c-myc is expressed in normal trout cells as a single 2.3-kb mRNA species, similar in size to other vertebrate transcripts.
Proceedings of the National Academy of Sciences of the United States of America © 1986 National Academy of Sciences