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First Report of Putative Streptococcus pneumoniae Serotype 6D among Nasopharyngeal Isolates from Fijian Children
Ping Jin, Fanrong Kong, Meng Xiao, Shahin Oftadeh, Fei Zhou, Chunyi Liu, Fiona Russell and Gwendolyn L. Gilbert
The Journal of Infectious Diseases
Vol. 200, No. 9 (1 November 2009), pp. 1375-1380
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/27794230
Page Count: 6
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Background. A putative Streptococcus pneumoniae serotype, 6D, resulting from the introduction of wciN β into serotype 6B has been proposed. Methods. We studied 98 unique serogroup 6 isolates from Fijian children, two-thirds of whom had received at least 1 dose of 7-valent pneumococcal conjugate vaccine, and 51 invasive isolates from Australian children. We used a polymerase chain reaction (PCR) system that targets both wciNβ and the single-nucleotide polymorphism that differentiates serotypes 6A and 6B—wciP584g (6A) and wciP584a (6B). Results. Two (9%) of 22 Australian isolates and 24 (38%) of 64 Fijian isolates previously identified as 6A by the Quellung reaction and wciP584g PCR contained wciNβ and were designated as 6C; 14 (41%) of 34 Fijian isolates previously identified as 6B by the Quellung reaction and wciP584a PCR contained wciNβ and were designated as the new putative serotype 6D. A significantly smaller proportion of children from whom serotype 6D was isolated (2/14 [14%]) had not received PCV-7, compared with the proportion of those from whom serotype 6B was isolated (11/20 [55%]) (P < .05). Conclusion. This is the first report of naturally occurring S. pneumoniae serotype 6D.
The Journal of Infectious Diseases © 2009 Oxford University Press