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Borrelia burgdorferi Stimulates Macrophages to Secrete Higher Levels of Cytokines and Chemokines than Borrelia afzelii or Borrelia garinii

Klemen Strle, Elise E. Drouin, Shiqian Shen, Joseph EI Khoury, Gail McHugh, Eva Ruzic-Sabljic, Franc Strle and Allen C. Steere
The Journal of Infectious Diseases
Vol. 200, No. 12 (15 December 2009), pp. 1936-1943
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/27794367
Page Count: 8
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Borrelia burgdorferi
              Stimulates Macrophages to Secrete Higher Levels of Cytokines and Chemokines than
              Borrelia afzelii
              or
              Borrelia garinii
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Abstract

To delineate the inflammatory potential of the 3 pathogenic species of Borrelia burgdorferi sensu lato, we stimulated monocyte-derived macrophages from healthy human donors with 10 isolates each of B. burgdorferi, Borrelia afzelii, or Borrelia garinii recovered from erythema migrans skin lesions of patients with Lyme borreliosis from the United States or Slovenia. B. burgdorferi isolates from the United States induced macrophages to secrete significantly higher levels of interleukin (IL)-8, CCL3, CCL4, IL-6, IL-10, and tumor necrosis factor than B. garinii or B. afzelii isolates. Consistent with this response in cultured macrophages chemokine and cytokine levels in serum samples of patients from whom the isolates were obtained were significantly greater in B. burgdorferi–infected patients than in B. afzelii– or B. garinii–infected patients. These results demonstrate in vitro and in vivo that B. burgdorferi has greater inflammatory potential than B. afzelii and B. garinii, which may account in part for variations in the clinical manifestations of Lyme borreliosis.

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